Biopsy Technique

An ellipse of mucosa is removed with the scalpel blade with ideal minimal dimensions of 10 x 6 mm and tissue to a depth of 3 mm. The area sampled is selected to represent the most significant area of the lesion and to include the interface with adjacent normal tissues. It is a common misconception that the normal tissue is required to allow comparison with the diseased areas; rather the presence of normal tissue facilitates biopsy handling in that a stabilizing suture may be placed through the normal tissue without distorting the abnormal tissue. The tissue is placed in a fixative or onto orientation filter paper. The wound is repaired with sutures.

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