The consistent damage of blood vessels documented with advancing age in the body also affects the cerebral arteries with the outcome of a significant reduction of blood supply to the brain. As a consequence, selective loss of nerve cells and infarcts may occur and these alterations may lead to the aggravating dementing process of multinfarct dementia. Since atherosclerosis and amyloid angiopathy are reported to represent the most important changes responsible for the age-related progressive decay in blood cerebral perfusion, they were thoroughly investigated in the brain of both humans and experimental animal models. The results have provided detailed information on mechanisms, determinants, and the many causative events involved in these alterations of the aging brain.
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