Evan T. Keller, Jill M. Keller, and Gavin Gillespie
Zebrafish (Danio rerio) have been extensively utilized for understanding mechanisms of development. These studies have led to a wealth of resources including genetic tools, informational databases, and husbandry methods. In spite of all these resources, zebrafish have been underutilized for exploring the pathophysiology of disease and the aging process. Zebrafish offer several advantages over mammalian models for these studies, including the ability to perform saturation mutagenesis and the capability to contain thousands of animals in a small space. In this review, we will discuss the use of mature zebrafish as an animal model. The challenges of developing and maintaining a colony of aging zebrafish will be addressed. Specific examples to support the use of mature zebrafish as an animal model will be provided, including the demonstration of clinical pathology and that age-associated changes in various phenotypes can be observed in aging zebrafish.
Was this article helpful?
When it comes to reducing wrinkles, you really have to take your needs seriously. There are a number of factors that play a role in the health and well being of your skin. It is often hard to understand how products work and why they may not work even if they promise to do so. If you are considering wrinkle creams and a regimen of facelifts, you may go broke in the process. Before you do all of that, consider going through a process of determine the very best solution for your needs.