Table 422

Caspase-9 and -3 activation and PARP cleavage in the different models of hypoxia-ischemia or stroke in adult and neonatal rodent brains. Caspase-9 and caspase-3 activities were determined by fluorogenic LEDH and DEVD substrate cleavage, respectively. The presence of the 89 kDa of the PARP, poly (ADP-ribose) polymerase, a caspase-3 substrate, was described to be an apoptotic feature.

LEDHase activity

DEVDase activity

PARP cleavage

Model

Animal

(Caspase-9)

(Caspase-3)

(89 kDa)

Reference

tMCAo

Rat

-30%/control activity at 24 h

+ 58%/control activity at 6-12 h

6 to 48 h

Cho et al., 2003

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