Table 292

Telomerase activity, telomere shortening and ease of immortalization in vertebrate model systems

Mouse

Human

Chicken

Telomerase activity in somatic cells

No division-dependent telomere shortening

Fibroblasts spontaneously immortalize

No telomerase activity in most somatic cells

Division-dependent telomere shortening

Fibroblasts refractory to spontaneous immortalization

No telomerase activity in most somatic cells

Division-dependent telomere shortening

Fibroblasts refractory to spontaneous immortalization excellent review of the developmental regulation of telomerase activity in human, mouse, chicken and flowering plants, see Forsyth et al. (2002).

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