Systems Biology Model Applications

Given the evidence that the clinical presentation of frailty is likely a cumulative outcome of several levels of interrelationships between physiologic systems and probably molecular systems that ultimately impact clinical vulnerability, application of systems biologic approaches may be helpful in elucidating ultimate causes and key biologic processes from within this biologic web. The important interconnections between clinical, physiologic, and biologic levels of organismal functioning, although still hypothetical, may contribute to biological stability of an organism. If these interconnections are lost, then hypothetically, the organism is at high risk for the development of the vulnerability and clinical presentation of frailty (Fried et al., 2005). When intact, this complex, integrated web of systems offers redundancy and the ability to compensate effectively for stressors. The web of interconnectedness between systems suggests that frailty may present a new theoretical model for systems biology approaches. Kitano et al. (2002) has proposed that the structure and dynamics of cellular and organismal function must be examined to understand biology at the system level, rather than the characteristics of isolated parts of a cell or organism. Frailty research may benefit from the development of models where robustness in the face of stressors, multiple levels of cellular and organismal function, communication networks, and the relationship of these system properties to the clinical presentation are all entered into the model. In addition, frailty research may benefit from the development of models where feedback between components of clinical presentation and physiologic dysregulation may impact cellular and organism function and molecular characteristics (Csete et al., 2002).

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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