Serum Glucose And Insulin Under Notfasting And Fasting Conditions

During the feeding cycle in our laboratory, blood glucose levels did not statistically differ among (—/—)-AL, (tg/—)-AL, and (tg/tg)-AL groups, although the number of rats examined was limited (Table 31.1). In the CR groups, (—/—) and (tg/—) rats, blood glucose levels tended to be slightly decreased, although this difference was statistically insignificant. Serum insulin concentrations were significantly decreased in (tg/—)-AL and (tg/tg)-AL rats compared with (—/—)-AL rats (Table 31.1). In the CR groups, serum insulin was not significantly increased even in the CR1 phase even though (—/—)-CR and (tg/—)-CR rats consumed the same amount of food as each AL group overnight.

Data on fasting blood glucose and insulin concentrations were obtained by glucose tolerance tests. The blood glucose concentration in the tail vein after overnight fasting did not differ between (—/—) and (tg/—) rats, although it was slightly reduced in (tg/tg) rats, particularly at the age of 24 or 25 months (Table 31.5). Neither CR nor age affected blood glucose levels. Serum insulin concentrations were slightly, but significantly, lower in (tg/—) rats than (—/—) rats. This concentration significantly increased in the old group, but was insignificantly altered in the CR group. These data indicate that insulin resistance is already apparent in (—/—) and (tg/—) rats at old age, even if subjected to CR. It remains to be elucidated whether CR delays the occurrence of insulin resistance in middle age.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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