One striking result to come from SCNT studies is the apparent extension of replicative potential that accompanies the process. This is most apparent where serial nuclear transfer has been undertaken. This is the process of producing cloned embryos or progeny, recloning using donor cells from that cloned individual, and repeating the process for a number of generations.
This has been performed in both cattle (Stice and Keefer, 1993; Puera and Trounson, 1998) and mice (Wakayama et al., 2000). An additional type of serial NT indicative of expanded replicative potential involves not repeated rounds of NT, but rather the derivation of NT ESCs, which are then employed as nuclear donors for cloning. Thus, with nuclear transplantation, it is possible to entice adult somatic cell genomes to undergo extensive replication, illustrating an expanded replicative potential relative to the original donor cells.
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