Grow Younger Blood

Longevity Health and Wellness Protocol

Get Instant Access

Arnheim, N. and Cortopassi, G. (1992). Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res 275, 157-167.

Artandi, S.E., Chang, S., Lee, S.-L., Alson, S., Gottlieb, G.J., Chin, L., and DePinho, R.A. (2000). Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641-645.

Baker, D.J., Jeganathan, K.B., Cameron, J.D., Thompson, M., Juneja, S., Kopecka, A. et al. (2004). BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 36, 744-749.

Bartke, A. and Brown-Borg, H. (2004). Life extension in the dwarf mouse. Curr Top Dev Biol 63, 189-225.

Bartke, A., Chandrashekar, V., Bailey, B., Zaczek, D., and Turyn, D. (2002). Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36, 201-208.

Bergo, M.O., Gavino, B., Ross, J., Schmidt, W.K., Hong, C., Kendall, L.V. et al. (2002). Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci USA 99, 13049-13054.

Blackburn, E.H. (2005). Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett 579, 859-862.

Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A. et al. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34.

Bronson, R.T. and Lipman, R.D. (1991). Reduction in rate of occurrence of age-related lesions in dietary restricted laboratory mice. Growth, Development & Aging 55, 169-184.

Campisi, J. (2005). Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522.

Cao, L., Li, W., Kim, S., Brodie, S.G., and Deng, C.X. (2003). Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 17, 201-213.

Chang, S., Multani, A.S., Cabrera, N.G., Naylor, M.L., Laud, P., Lombard, D. et al. (2004). Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36, 877-882.

Cheng, H.L., Mostoslavsky, R., Saito, S., Manis, J.P., Gu, Y., Patel, P. et al. (2003). Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100, 10794-10799.

Chun, H.H. and Gatti, R.A. (2004). Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 3, 1187-1196.

de Boer, J., Andressoo, J.O., de Wit, J., Huijmans, J., Beems, R.B., van Steeg, H. et al. (2002). Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276-1279.

de Boer, J., de Wit, J., van Steeg, H., Berg, R.J., Morreau, H., Visser, P. et al. (1998). A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol Cell 1, 981-990.

de Vries, A., van Oostrom, C.T., Hofhuis, F.M., Dortant, P.M., Berg, R.J., de Gruijl, F.R. et al. (1995). Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377, 169-173.

DePinho, R.A. (2000). The age of cancer. Nature 408, 248-254.

Difilippantonio, M.J., Zhu, J., Chen, H.T., Meffre, E., Nussenzweig, M.C., Max, E.E. et al. (2000). DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404, 510-514.

Dolle, M.E. and Vijg, J. (2002). Genome dynamics in aging mice. Genome Res 12, 1732-1738.

Dolls:, M.E.T., Busuttil, R.A., Garcia, A.M., Wijnhoven, S., van Drunen, A., Niedernhofer, L.J., van der Horst, G., Hoeijmakers, J.H.J., van Steeg, H., and Vijg, J. Increased genomic instability is not a prerequisite for shortened life span in DNA repair deficient mice. Mutation Research, in press.

Dumble, M., Gatza, C., Tyner, S., Venkatachalam, S., and Donehower, L.A. (2004). Insights into aging obtained from p53 mutant mouse models. Ann N Y Acad Sci 1019, 171-177.

Epstein, C.J., Martin, G.M., and Motulsky, AG. (1965). Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases. Trans Assoc Am Physicians 78, 73-81.

Eriksson, M., Brown, W.T., Gordon, L.B., Glynn, M.W., Singer, J., Scott, L. et al. (2003). Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293-298.

Espejel, S., Martin, M., Klatt, P., Martin-Caballero, J., Flores, J.M., and Blasco, M.A. (2004). Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep 5, 503-509.

Fukuchi, K., Martin, G.M., and Monnat, R.J., Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 86, 5893-5897.

Gangloff, S., McDonald, J.P., Bendixen, C., Arthur, L., and Rothstein, R. (1994) The yeast type I topoisomerase Top3 interacts with Sgsl, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol 14, 8391-8398.

Garcia-Cao, I., Garcia-Cao, M., Martin-Caballero, J., Criado, L.M., Klatt, P., Flores, J.M. et al. (2002). "Super p53'' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. Embo J 21, 6225-6235.

Goto, M. (1997). Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev 98, 239-254.

Gruenbaum, Y., Margalit, A., Goldman, R.D., Shumaker, D.K., and Wilson, K.L. (2005). The nuclear lamina comes of age. Nat Rev Mol Cell Biol 6, 21-31.

Gu, Y., Seidl, K.J., Rathbun, G.A., Zhu, C., Manis, J.P., van der Stoep, N. et al. (1997). Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 653-665.

Hamilton, M.L., Van Remmen, H., Drake, J.A., Yang, H., Guo, Z.M., Kewitt, K. et al. (2001). Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA 98, 10469-10474.

Hanks, S. and Rahman, N. (2005). Aneuploidy-cancer predisposition syndromes: a new link between the mitotic spindle checkpoint and cancer. Cell Cycle 4, 225-227.

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., and Vijg, J. (2003). Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359.

Hasty, P. and Vijg, J. (2004). Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3, 55-65.

Hoeijmakers, J.H. (2001). Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374.

Hosaka, T., Biggs, W.H., 3rd, Tieu, D., Boyer, A.D., Varki, N.M., Cavenee, W.K. et al. (2004). Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 101, 2975-2980.

Jenkins, N.L., McColl, G., and Lithgow, G.J. (2004). Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci 271, 2523-2526.

Kile, B.T., Hentges, K.E., Clark, A.T., Nakamura, H., Salinger, A.P., Liu, B. et al. (2003). Functional genetic analysis of mouse chromosome 11. Nature 425, 81-86.

Kirkwood, T.B. (2005). Understanding the odd science of aging. Cell 120, 437-447.

Kirkwood, T.B. and Cremer, T. (1982). Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet 60, 101-121.

Kujoth, G.C., Hiona, A., Pugh, T.D., Someya, S., Panzer, K., Wohlgemuth, S.E., Hofer, T., Seo, A.Y., Sullivan, R., Jobling, W.A., Morrow, J.D., Van Remmen, H., Sedivy, J.M., Yamasoba, T., Tanokura, M., Weindruch, R., Leeuwenburgh, C., and Prolla, T.A. (2005). Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309, 481-484.

Kwan, K.Y. and Wang, J.C. (2001). Mice lacking DNA topoiso-merase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci USA 98, 5717-5721.

Laursen, L.V., Bjergbaek, L., Murray, J.M., and Andersen, A.H. (2003). RecQ helicases and topoisomerase III in cancer and aging. Biogerontology 4, 275-287.

Lebel, M., Cardiff, R.D., and Leder, P. (2001). Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 61, 1816-1819.

Lebel, M. and Leder, P. (1998). A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95, 13097-13102.

Lehmann, A.R. (2003). DNA repair-deficient diseases, xero-derma pigmentosum, Cockayne syndrome and trichothio-dystrophy. Biochimie 85, 1101-1111.

Lindor, N.M., Furuichi, Y., Kitao, S., Shimamoto, A., Arndt, C., and Jalal, S. (2000). Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am J Med Genet 90, 223-228.

Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J., Pei, D., Pendas, A.M., Cadinanos, J., Lopez-Otin, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S., Tryggvason, K., and Zhou, Z. (2005). Genomic instability in laminopathy-based premature aging. Nat Med 11, 780-785.

Lombard, D.B., Beard, C., Johnson, B., Marciniak, R.A., Dausman, J., Bronson, R. et al. (2000). Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol 20, 3286-3291.

Lombard, D.B., Chua, K.F., Mostoslavsky, R., Franco, S., Gostissa, M., and Alt, F.W. (2005). DNA repair, genome stability, and aging. Cell 120, 497-512.

Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T. et al. (2004). Modulation of mammalian life span by the short isoform of p53. Genes Dev 18, 306-319.

Martin, G.M. (2005). Genetic modulation of senescent pheno-types in Homo sapiens. Cell 120, 523-532.

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P.P. et al. (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313.

Motta, M.C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W. et al. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563.

Mounkes, L.C., Kozlov, S., Hernandez, L., Sullivan, T., and Stewart, C.L. (2003). A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423, 298-301.

Nussenzweig, A., Chen, C., da Costa Soares, V., Sanchez, M., Sokol, K., Nussenzweig, M.C. et al. (1996). Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382, 551-555.

Pollex, R.L. and Hegele, R.A. (2004). Hutchinson-Gilford progeria syndrome. Clin Genet 66, 375-381.

Poot, M., Gollahon, K.A., and Rabinovitch, P.S. (1999). Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum Genet 104, 10-14.

Robanus-Maandag, E., Dekker, M., van der Valk, M., Carrozza, M.L., Jeanny, J.C., Dannenberg, J.H. et al. (1998). p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev 12, 1599-1609.

Rudolph, K.L., Chang, S., Lee, H.W., Blasco, M., Gottlieb, G.J., Greider, C. et al. (1999). Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701-712.

Shiloh, Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3, 155-168.

Tarsounas, M. and West, S.C. (2005). Recombination at mammalian telomeres: An alternative mechanism for telo-mere protection and elongation. Cell Cycle 4.

Tatar, M., Bartke, A., and Antebi, A. (2003). The endocrine regulation of aging by insulin-like signals. Science 299, 1346-1351.

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J.N., Rovio, A.T., Bruder, C.E. et al. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.

Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H. et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53.

Van Gent, D.C., Hoeijmakers, J.H., and Kanaar, R. (2001). Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2, 196-206.

Varela, I., Cadinanos, J., Pendas, A.M., Gutierrez-Fernandez, A., Folgueras, A.R., Sanchez, L.M., Zhou, Z., Rodriguez, F.J., Stewart, C.L., Vega, J.A., Tryggvason, K., Freije, J.M., and Lopez-Otin, C. (2005). Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437, 564-568.

Vijg, J. and Dolle, M.E. (2002). Large genome rearrangements as a primary cause of aging. Mech Ageing Dev 123, 907-915.

Vijg, J. and Suh, Y. (2005). Genetics of longevity and aging. Annual Review of Medicine 56.

Vogel, H., Lim, D.S., Karsenty, G., Finegold, M., and Hasty, P. (1999). Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA 96, 10770-10775.

Vogelstein, B., Lane, D., and Levine, A.J. (2000). Surfing the p53 network. Nature 408, 307-310.

Wallis, J.W., Chrebet, G., Brodsky, G., Rolfe, M., and Rothstein, R. (1989). A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58, 409-419.

Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R., Vissers, C.J., et al. (1997). Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol 7, 427-439.

Wijnhoven, S.W., Beems, R.B., Roodbergen, M., van den Berg, J., Lohman, P.H., Diderich, K., van der Horst, G.T., Vijg, J., Hoeijmakers, J.H., and van Steeg, H. (2005). Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair 4, 1314-1324.

Williams, G.C. (1957). Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411.

Wise, P.M., Kashon, M.L., Krajnak, K.M., Rosewell, K.L., Cai, A., Scarbrough, K. et al. (1997). Aging of the female reproductive system: a window into brain aging. Recent Prog Horm Res 52, 279-303; discussion 303-305.

Wong, K.K., Maser, R.S., Bachoo, R.M., Menon, J., Carrasco, D.R., Gu, Y. et al. (2003). Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421, 643-648.

Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S., and Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10, 2411-2422.

Yu, C.E., Oshima, J., Fu, Y.H., Wijsman, E.M., Hisama, F., Alisch, R. et al. (1996). Positional cloning of the Werner's syndrome gene. Science 272, 258-262.

Was this article helpful?

0 0
How to Stay Young

How to Stay Young

For centuries, ever since the legendary Ponce de Leon went searching for the elusive Fountain of Youth, people have been looking for ways to slow down the aging process. Medical science has made great strides in keeping people alive longer by preventing and curing disease, and helping people to live healthier lives. Average life expectancy keeps increasing, and most of us can look forward to the chance to live much longer lives than our ancestors.

Get My Free Ebook

Post a comment