Alexeyev, M.F., LeDoux, S.P., and Wilson, G.L. (2004).
Mitochondrial DNA and aging. Clin. Sci. 107, 355-364. Barja, G. (2004). Free radicals and aging. Trends Neurosci. 27, 595-600.
Capps, G.J., Samuels, D.C., and Chinnery, P.F. (2003). A model of the nuclear control of mitochondrial DNA replication. J. Theor. Biol. 221, 565-583. Chinnery, P.F. and Samuels, D.C. (1999). Relaxed replication of mtDNA: A model with implications for the expression of disease. Am. J. Hum. Genet. 64, 1158-1165. Chinnery, P.F., Samuels, D.C., Elson, J., and Turnbull, D.M.
(2002). Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism? Lancet 360, 1323-1325.
Elson, J.L., Samuels, D.C., Turnbull, D.M., and Chinnery, P.F. (2001). Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 68, 802-806. Herrero, A. and Barja, G. (1999). 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging. Aging-Clin. Exp. Res. 11, 294-300. Huang, H. and Manton, K.G. (2004). The role of oxidative damage in mitochondria during aging: A review. Front. Biosci. 9, 1100-1117. Kirkwood, T.B.L. and Proctor, C.J. (2003). Somatic mutations and ageing in silico. Mech. Ageing Dev. 124, 85-92. Kowald, A. and Kirkwood, T.B.L. (1993). Mitochondrial Mutations, Cellular-Instability and Aging—Modeling the Population-Dynamics of Mitochondria. Mutat. Res. 295, 93-103.
Kowald, A. and Kirkwood, T.B.L. (2000). Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. J. Theor. Biol. 202, 145-160. Kraytsberg, Y., Nekhaeva, E., Bodyak, N.B., and Khrapko, K.
(2003). Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? Mech. Ageing Dev. 124, 49-53.
Nekhaeva, E., Bodyak, N.D., Kraytsberg, Y., McGrath, S.B., Van Orsouw, N.J., Pluzhnikov, A. et al. (2002a). Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc. Natl. Acad. Sci. USA 99, 5521-5526.
Nekhaeva, E., Kraytsberg, Y., and Khrapko, K. (2002b;). mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self'. Mech. Ageing Dev. 123, 891-898.
Press, W.H., Flannery, B.P., Teukolsky, S.A., and Vetterling, W.T. (1988). Numerical Recipes in C. Cambridge: Cambridge University Press.
Rajasimha, H.K., Samuels, D.C., and Nance, R.E. (2004). A simulation methodology in modeling cell divisions with stochastic effects. Proc. 2004; Winter Sim. Conf. 2032-2038.
Samuels, D.C. (2004). Mitochondrial DNA repeats constrain the life span of mammals. Trends Genet. 20, 226-229.
Samuels, D.C. (2005). Life span is related to the free energy of mitochondrial DNA. Mech. Ageing. Dev., 126, 1123-1129.
Skulachev, V.P. (2004). Mitochondria, reactive oxygen species and longevity: some lessons from the Barja group. Aging Cell 3, 17-19.
Sozou, P.D. and Kirkwood, T.B.L. (2001). A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J. Theor. Biol. 213, 573-586.
Taylor, R.W., Taylor, G.A., Durham, S.E., and Turnbull, D.M. (2001). The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations. Nucleic Acids Res. 29, art. no.-e74.
Taylor, R.W., Barron, M.J., Borthwick, G.M., Gospel, A., Chinnery, P.F., Samuels, D.C. et al. (2003). Mitochondrial DNA mutations in human colonic crypt stem cells. J. Clin. Invest. 112, 1351-1360.
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A.T., Bruder, C.E. et al. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.
Wang, E.D., Wong, A., and Cortopassi, G. (1997). The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat. Res.-Fundam. Mol. Mech. Mutagen. 377, 157-166.
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