Figure 42.4 Effect of pan-caspase inhibitors on infarct volume measured 48 hours after neonatal ischemia in P7 rat brain (neonatal stroke model). The drug was given five minutes before clip removal and consisted of a single intraperitoneal injection of either BAF in 10% DMSO (n = 16) or vehicle (10% DMSO, n = 15) (A) or Q-VD-OPH (B, see text). Control ischemic rats (n =14 and 16, respectively) also were studied. Data are mean ± SEM (bar). BAF did not induce a significant reduction of infarct volume (N.S., not significant) as compared to Q-VD-OPH (p = 0.04, Mann-Whitney test).

Pretreatment with subthreshold doses of the NMDA receptor antagonist MK-801 and delayed treatment with subthreshold doses of zVAD-fmk provided synergistic protection compared with each treatment alone (Schulz et al., 1998). Moreover, both treatments extended the therapeutic window for caspase inhibition for an additional two to three hours. Further, pretreatment with subthreshold doses of zVAD-fmk extended the therapeutic window for MK-801 by two hours (Ma et al., 1998; Schulz et al., 1998). These data suggest the potential value of combining treatment strategies to reduce side effects and extend the treatment window in cerebral ischemia.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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