In recent years, protein kinase C has emerged as a potential target for therapeutic agents that reduce the risk of complications in diabetes. PKC is a calcium-dependent enzyme involved in signal transduction through changes in the phosphorylation of key cellular proteins. High blood glucose levels increase phospholipase D activity, which in turn, activates the membrane-bound PKC. This activation accounts at least in part for the increased cell permeability and vascular resistance. In pathological state of hyperglycemia, diacylglycerol (DAG) content is increased, which along with the increased oxidative
Biochemical Pathways Activating PKC b
Physiological Conditions: Pathological Conditions: Euglycemia
Phospholipase C \
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...