Poly Adpribose Polymerase Parp Cleavage

PARP is a nuclear protein used for DNA repair. It is one of the prototype substrates for caspase-3-mediated cleavage and has been used in many systems to indicate the presence of activated caspase-3. Disappearance of the full-length (116 kDa) PARP and appearance of the cleavage product 89 kDa allow identification of caspase-3-mediated apoptosis (Duriez and Shah, 1997; Casiano et al., 1998). PARP cleavage into the 89 kDa protein was identified in adult and neonatal models of cerebral hypoxia-ischemia, in studies that demonstrated caspase-3 activation (see Table 42.2).

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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