Plasma Leptin

Plasma leptin concentrations are known to reflect body fat content (Niswender and Schwartz, 2003). At the age between 6 and 8 months, plasma concentrations did not significantly differ among rat groups, although the fat content was slightly lower in (tg/tg) rats compared with

Perirenal Fat Rat

Figure 31.5. (A) Body fat content, and (B) plasma leptin and (C) adiponectin concentrations. The body fat content represents the combined wet weights of perirenal and epididymal fat normalized by body weight (g/100 g body weight (BW)). Fat content did not significantly differ between the CR1 and CR2 phase rats; thus data were combined into the CR group. Plasma samples were prepared from trunk blood collected at decapitation. Plasma leptin and adiponectin data was unavailable for (tg/tg) rats. ''Young'' represents an age of 6 to 8 months, while ''Old'' represents an age of 24 to 25 months. The numbers of rats examined were 7 to 24 for body fat content, 3 to 8 for plasma leptin, and 3 to 7 for plasma adiponectin. 3-f ANOVA was used to analyze the main effects of rat group, diet, and age and their interaction.

Figure 31.5. (A) Body fat content, and (B) plasma leptin and (C) adiponectin concentrations. The body fat content represents the combined wet weights of perirenal and epididymal fat normalized by body weight (g/100 g body weight (BW)). Fat content did not significantly differ between the CR1 and CR2 phase rats; thus data were combined into the CR group. Plasma samples were prepared from trunk blood collected at decapitation. Plasma leptin and adiponectin data was unavailable for (tg/tg) rats. ''Young'' represents an age of 6 to 8 months, while ''Old'' represents an age of 24 to 25 months. The numbers of rats examined were 7 to 24 for body fat content, 3 to 8 for plasma leptin, and 3 to 7 for plasma adiponectin. 3-f ANOVA was used to analyze the main effects of rat group, diet, and age and their interaction.

(—/—) and (tg/—) rats (Figure 31.5B). The CR regimen in the present study reduced plasma leptin levels only in the CR2 phase rats. However, in our previous study using F344 rats, leptin levels were consistently lower in the CR group during the 2-day feeding cycle (Shimokawa and Higami 1999). The plasma leptin findings paralleled the altered fat content resulting from CR.

With aging, plasma leptin concentrations were slightly increased in the AL group, staying constant or slightly decreased in the CR group. These aging-dependent changes were also comparable with the changes in fat content.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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