Other Prominent Clinical Features Of Werner Syndrome

Several less consistent clinical findings have been noted in a portion of WS patients. These additional findings (see Table 80.1) have been mentioned in many independent reports of WS, and thus are likely to be part—albeit a more variable part—of the WS pheno-type. Most notable among these changes are clinically important disease states that we commonly associate with aging: atherosclerosis and its cardiovascular and cerebral sequella; a mix of nonepithelial and epithelial neoplasms (see later); osteoporosis that is characteristically most severe in the distal phalanges; diabetes mellitus; and hypogonadism affecting both males and females. Each of these disease states in part can be explained by proliferative and atrophic changes at the tissue level (see later). A few pertinent negatives also need to be mentioned. Among these, the most notable are that development, structure, and function of the central and peripheral nervous systems are normal, and WS patients are invariably of normal or higher-than-normal intelligence. Also, few or no indications of primary endocrine defects or abnormalities have been reported in WS patients beyond secondary changes that accompany the development of diabetes mellitus or with gonadal atrophy and the loss of reproductive function.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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