This is the most abundant osteoblast-specific non-collagenous protein (Ducy et al., 1996) (see Figure 58.1). Osteocalcin-deficient mice develop a phenotype characterized by higher bone mass with increased functional quality (Ducy et al., 1996). These mice, however, do not exhibit vascular calcification, indicating that OC is primarily operative in the bone rather than the vascular tissues. The expression of OC and MGP in humans is parallel in normal as well as in atherosclerotic tissues (Dhore et al., 2001).
In women with osteoporosis and atherosclerosis, serum OC is elevated (Bini et al., 1999), suggesting an integral role of Gla protein in both vascular wall and bone.
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...