Neuropathology

In parallel with our work on characterizing cognitive and behavioral changes in aging dogs, a third strategy in developing the canine as a model system of human brain aging involves identifying pathological brain changes related to age-associated cognitive-behavioral dysfunction in the dog. Specifically, we have examined beta-amyloid deposition, neuron loss, oxidative damage, and structural anatomy in the aging canine brain. These studies reveal that brain aging in dogs begins as early as middle age, varies across brain regions, and correlates with cognitive and behavioral impairments; dogs develop some of the pathological hallmarks found in Alzheimer's disease. This final section will summarize current knowledge on neuropathological and neuroanatomical markers of brain aging in the canine.

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