Neuropathology

In parallel with our work on characterizing cognitive and behavioral changes in aging dogs, a third strategy in developing the canine as a model system of human brain aging involves identifying pathological brain changes related to age-associated cognitive-behavioral dysfunction in the dog. Specifically, we have examined beta-amyloid deposition, neuron loss, oxidative damage, and structural anatomy in the aging canine brain. These studies reveal that brain aging in dogs begins as early as middle age, varies across brain regions, and correlates with cognitive and behavioral impairments; dogs develop some of the pathological hallmarks found in Alzheimer's disease. This final section will summarize current knowledge on neuropathological and neuroanatomical markers of brain aging in the canine.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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