N M

6 hours 24 hours

Time post-ischemia

48 hours

Figure 42.3 Apoptosis in the ipsilateral cortex after neonatal stroke in 7-day-old rat. A-B: Typical illustration of DNA fragmentation by the TUNEL assay in the core (A) and penumbra (B), 24 hours post-ischemia. Note the presence of a few necrotic neurons (white arrows in A) near apoptotic nuclei in the core and numerous apoptotic bodies in both the core and penumbra (insert in B). Bar represents 50 (A, B) and 25 mm (insert in B). C: Evolution of the Bax/Bcl-2 positive cell ratio in the cerebral cortex. Immunohistochemical studies were performed at 6, 24, and 48 h post-ischemia. No Bcl-2 positive cells and a few (2 to 4) Bax positive cells were detected in controls. The data represent mean values ± S.D. obtained from three separate experiments. Note a rapid Bax/Bcl-2 ratio increase in the core during time of reperfusion. In contrast, the Bax/Bcl-2 ratio evolution was delayed in the penumbra.

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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