Models for Apoptosis From Newborn to Adult

Christiane Charriaut-Marlangue and Sylvain Renolleau

Neurodegenerative diseases are characterized by progressive impairment of brain function as a consequence of ongoing neuronal cell death. Apoptotic mechanisms have been implicated in this process, but the immature brain differs from the adult brain in its sensitivity. To better understand the pathogenesis and developmental variations of hypoxic-ischemic neuronal death, several models have been developed and investigated to characterize cell death features in the developing brain. Involvement of apoptosis-relatedproteins such as Bax/Bcl-2 and caspases is overviewed during development and hypoxic-ischemic injury in various models.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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