Mikhail F. Alexeyev, Susan P. LeDoux, and Glenn L. Wilson
The goal of this chapter is to introduce the reader to the current state of the mitochondrial theory of aging as it pertains to mitochondrial DNA (mtDNA). Several aspects will be covered, including a basic biology of mitochondrial DNA, the experimental evidence supporting the mitochondrial theory of aging, and the experimental data that appear to contradict this theory. Finally, an overview of experimental approaches used to study mtDNA in aging will be presented, and weaknesses of each approach will be discussed.
Was this article helpful?
Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...