Robert Arking

Flies show three different types of longevity phenotypes, only one of which is characterized by significant increases in both the mean and maximum life span. This arises as a result of an experimentally induced delay in the onset of senescence. The net result of this phenotype is a significant increase in the length of the ''health span," coupled with no significant change in the ''senescent span.'' It is the purpose of this chapter to summarize what we know about the gene expression patterns and pathways that appear to be critically involved in allowing the expression of the one longevity phenotype which extends longevity by delaying the onset of senescence.

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