Insulin Receptor Signaling

Insulin and insulin-like growth factor-1 (IGF-1) signaling pathways have been implicated in aging of several experimental organisms (Pardee et al., 2004). This pathway is critical to coordinating the influx of calories with the metabolic rate. Down-regulation of this pathway through caloric restriction is associated with increased life span in mice, worms, flies, and yeast (Barbieri et al., 2003). One of the key transcription factors implicated in aging, namely, FOXO, is regulated by insulin and IGF-1. The FOXO homolog in worms, DAF-16, has a central role in imparting longevity of worms with mutations in the insulin/IGF-1 signaling pathway genes, such as daf-2 and age-1 (Kenyon et al., 1993). Over-expression of dFOXO in worms and DAF-16 in flies extends life span through interactions with a host of other nuclear receptors, particularly the PPARs (Giannakou et al., 2004; Henderson and Johnson, 2003). These receptors are up-regulated during caloric restriction, and overexpression of PPAR S in transgenic mice is associated with

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment