with several genetic alternations. This would be at least closer to the real multifactorial etiology of BPH in humans. On the other hand, the clinically relevant biological variability of human BPH can be reached only in spontaneous animal models, but the species-related differences to human BPH should always be kept in mind (Mahapokai et al., 2000). Tough major advances in this field of biomedical research are due to the cooperation of specialists—urologists, molecular biologists, and others. The hormonally induced BPH in rodent and canine animals will still be the most popular and most often used model at least for the next few years.

Recommended Resources

Bayne, C.W., Donnelly, F., Chapman, K., Bollina, P., Buck, C., and Habib, F. (1998). A novel coculture model for benign prostatic hyperplasia expressing both iso-forms of 5 alpha-reductase. J Clin Endocrinol Metab 83, 206-213.

A description of an in vitro model using the coculture technique.

Eaton, C.L. (2003). Aetiology and pathogenesis of benign prostatic hyperplasia. Curr Opin Urol 13, 7-10.

A short review about the pathogenesis of BPH.

Kindblom, J., Dillner, K., Sahlin, L., Robertson, F., Ormandy, C., Tornell, J. et al. (2003). Prostate hyper-plasia in a transgenic mouse with prostate-specific expression of prolactin. Endocrinology 144, 2269-2278.

Detailed analysis of one transgenic model of BPH using prostate-specific expression of prolactin.

Mahapokai, W., Van Sluijs, F.J., and Schalken, J.A. (2000). Models for studying benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 3, 28-33.

A short review about available research models of BPH.

Shappell, S.B., Thomas, G.V., Roberts, R.L., Herbert, R., Ittmann, M.M., Rubin, M.A. et al. (2004). Prostate pathology of genetically engineered mice: Definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee. Cancer Res 64, 2270-2305.

Histopathological review about transgenic mouse model for various prostate diseases.

Thorpe, A. and Neal, D. (2003). Benign prostatic hyperplasia. Lancet 361, 1359-1367.

Clinically oriented review about BPH.

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Blood Pressure Health

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