I

I. Intestinal Epithelium

Transport of # " Glucose

Membrane Physicochemical properties

Fluidity " #

Cholesterol/Phospholipid ratio NC "

Sphingomyelin/lecithin ratio " NC

II. Res Blood Cells

Life span NC #

Calmodulin content # NC

Transketolase # #

III. White Blood Cells

Calmodulin content NC #

Oxidative potential # #

Digestibility of DNA with alkali # #

IV. Platelets; Thromboxane synthesis NC "

V. Lymphocytes

1. Mitogenic response # #

2. IL2 production # NC

3. Single-strand DNA breaks " "

diabetes-related changes in the CNS and the changes seen commonly with age is remarkable. On the other hand, tissues with high replicative capacity such as intestinal epithelium and bone marrow do not demonstrate a high level of concordance between the changes in diabetes and those seen with age (see Table 56.2). These tissues do not appear to undergo premature aging in diabetes. It is likely that accelerated aging in diabetes is tissue-specific, and it may be limited to tissues without a high capacity of replication.

Hexosamine flux Polyol pathway

Hexosamine flux Polyol pathway

depletion ATP ase

Figure 56.1 Select metabolic pathways contributing to glucotoxicity.

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