High Throughput Approaches to Measuring Life Span in Simple Eukaryotes

Simple eukaryotic models, such as yeast, worms, and flies, have had a significant impact on aging-related research, largely due to their short life span and genetic tractabi-lity (see Chapters 17-25). Nearly all model-based studies of aging have been driven either by candidate gene approaches, where a particular gene is studied based on its known or assumed function related to aging, or by genetic screens for secondary phenotypes correlated with longevity. These approaches, while often fruitful, are inherently biased. The development of true high-throughput life span assays, where longevity can be measured for thousands of individuals simultaneously, provides the opportunity to identify genetic and environmental regulators of aging in an unbiased, genome-wide manner.

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