Global Model Of Ischemia

The global models of cerebral ischemia consist of a brief period of ischemia (5-15 min), during which complete arrest of cerebral blood flow to the brain is achieved, followed by reperfusion. The common models used are bilateral occlusion of the carotid arteries in gerbils (Cho et al., 2003), occlusion of vertebral arteries and carotid arteries (four-vessel occlusion, 4VO) for 10 to 20 min (Pulsinelli and Brierley, 1979) and occlusion of the carotid arteries (two-vessel occlusion, 2VO) with concomitant hypotension to 50 mm Hg for 5 to 15 min in rats (Gill et al., 2002). Global ischemia tends to result in delayed neuronal death in the hippocampus, cortex, and striatum. In general, this delayed degeneration is also believed to be necrotic (Petito et al., 1997), although DNA laddering and TUNEL-positive nuclei have been reported (Heron et al., 1993; MacManus et al., 1993; Ferrer et al., 1994b; MacManus et al., 1994). Prominent apoptotic cell death occurs following global ischemia in neuronal groups that are interconnected with selectively vulnerable populations of neurons and also in nonneuronal cells (Martin et al., 1998).

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment