Future Developments

The correlation between chaperones and aging/ longevity should be further examined with focus on the chaperone matrix of the inherently immortal embryonic stem cells.

With emphasis on DAN/RNA-chaperones it is proposed:

• To consider a more comprehensive characterization of the differences in the constitutive level of chaperone expression in relation to the life span of different species.

• To further investigate the effect on species life span of a constitutive increase in the expression of the various chaperones with emphasis on p68 (the putative mammalian analogue to the SV40 T-protein).

• To investigate means for a specific reactivation of chaperone genes silenced during aging as well as to stop the progressive silencing of chaperone genes during normal aging.

• To investigate the redundancy of function of the molecular chaperones to approach a definition of a minimal polymer folding system.

• To identify the chaperone of the large heat shock proteins (autonomous small Hsp's).

How To Add Ten Years To Your Life

How To Add Ten Years To Your Life

When over eighty years of age, the poet Bryant said that he had added more than ten years to his life by taking a simple exercise while dressing in the morning. Those who knew Bryant and the facts of his life never doubted the truth of this statement.

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