For Aging

Pudur Jagadeeswaran

Nothobranchius fish have a lifespan of approximately one year whereas zebrafish live up to 4-5 years. This finding suggested that if classical genetic approaches could be adapted to Nothobranchius, these annual fish would become an ideal vertebrate genetic model for studying longevity genes. In this chapter, we provide arguments and approaches for utilizing Nothobranchius to study the genetics of aging. Because Nothobranchius has a relatively short lifespan, has multiple strains, is a diploid organism, has high fecundity and most importantly is able to lay eggs until the end of their lives, this fish is an excellent animal model for studying genetics of vertebrate longevity. Various approaches to isolate long-lived mutants are described along with their utility for discovering antiaging drugs.

How to Stay Young

How to Stay Young

For centuries, ever since the legendary Ponce de Leon went searching for the elusive Fountain of Youth, people have been looking for ways to slow down the aging process. Medical science has made great strides in keeping people alive longer by preventing and curing disease, and helping people to live healthier lives. Average life expectancy keeps increasing, and most of us can look forward to the chance to live much longer lives than our ancestors.

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