Conclusions

Use of the primate as a model for aging is increasing, and the in vivo MRI-based studies enjoy the advantage of repeated measures, with each subject serving as its own baseline control. A controlled longitudinal study of the nonhuman primate, a moderately long-lived species with close phylogenetic ties with humans, could contribute to the brain-aging field in better defining age-related changes in gray and white matter, which are still somewhat controversial in the clinical literature. For example, with about a third of the maximum lifespan of humans, it would be feasible to compare repeat scans of individual monkeys at the critical middle-age to old and old to oldest-old transitions. In addition, with the increased usage of the monkey model and simultaneous evolution of MRI technology, the ability to explore anatomical loci with increasing sensitivity is rapidly evolving. Moreover, the generation of sophisticated neurochemical analysis and physiological measures by MRI will substantially augment existing behavioral and neurophysiological analyses in describing the neuro-biological underpinnings of brain function in the nonhuman primate model.

Compared to the rhesus monkey, there is no other well-characterized animal model with such extensive similarity to humans across a wide range of physiological responses. Rhesus monkeys share a significant portion of the genetic information found in humans and are more closely related to humans than rodents. This species has been extensively used in biomedical research and is among the best characterized of the nonhuman primates, particularly with respect to normal aging. Finally, these in vivo assays, coupled with neurochemical and histologi-cal approaches, will make a powerful approach to addressing aging of the brain, enable a more comprehensive assay of potential interventions, and translate well to the clinic.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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