The process of aging is characterized by a marked heterogeneity among individuals, a hallmark that is reflected also by the different groups of brain cells accomplishing different tasks. Although composed by fully differentiated postmitotic cells, the brain retains a consistent potential for adaptive response even in old individuals. Compensating reactions are actively counteracting age-related alterations, thus masking the decay of specific functions until a critical threshold of impairment is attained. Several determinants are reported to play a role in brain aging, and these may affect interdependent processes that, in turn, compromise the proper efficiency of selected neural network. As a final outcome, coping with environmental stimuli becomes increasingly difficult, particularly under excessive stimulation or stress, and impairment of function becomes clearly apparent. Current literature data support the idea that early disturbances occur on synaptic and mitochon-drial functions both in physiological aging and in the progressive pathogenesis of age-related neurodegenerative diseases. This suggests that both synapses and mitochondria may constitute reliable targets for early therapeutic interventions at least to decrease the severity of the alterations occurring in human brain aging.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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