In this chapter, we have detailed a method for the production and maintenance of human monoclonal T cell populations in long-term culture, and we have provided selected examples of protocols for analytic techniques with which to seek age-associated changes therein (biomarkers of aging). The model represents a situation of chronic antigenic stress, where TCC are constantly reexposed to stimulating antigen. There are reasons to believe that this model does reflect common challenges to the immune system in vivo, particularly in the elderly where the chronic stressor may be Herpes virus, particularly Cytomegalovirus (CMV) (Pawelec et al., 2004), but also in younger individuals carrying large antigenic loads that cannot be cleared (cancer patients, patients infected with persistent parasites, etc.). This chronic antigenic

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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