Bruchs Membrane

The Bruch's membrane extends from the optic disk to the ora serrata. Its thickness varies in different parts of the eye; it is thickest close to the optic disk (2-4 mm) and thinner at the periphery (1-2 mm). It is formed by the following five layers: (1) The basal membranes of the RPE cells form the inner layer of the Bruch's membrane; followed by (2) the internal collagen layer; (3) the elastic layer; (4) the external collagen layer; and (5) the basal membrane of the choriocapillaries. Collagen and elastane are the principal structural proteins of the Bruch's membrane. Certain types of collagen (type I, II, III, V, and IX) aggregate in long fibrils. Other types (IX and XIII) are found on the surface of the fibrils and are linked to other components of the matrix. Type IV collagen forms a soft net. The elastane fibers give elasticity to the membrane. Fibronectin and laminin are large glycoproteins, which, through their multiple bonds, help the cells to join to the membrane (Feeney-Burns and Ellersiek, 1985).

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Blood Pressure Health

Blood Pressure Health

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