AxBcl2 Regulation

In models of hypoxia, a significant elevation of the Bax/ Bcl-2 protein ratio was determined between 6 and 13 days following injury in the P0-1 rat brain (Daval and Vert, 2004). In contrast, the lack of significant variations of the expression of Bax and Bcl-2 proteins appeared to be in good agreement with the absence of detectable levels of apoptosis as a consequence of the hypoxic insult in P7 rats (Grojean et al., 2003). In the newborn piglet (P2-P5), the ratio of Bax to Bcl-2 proteins increased more than twofold during hypoxia as compared to normoxia (Ravishankar et al., 2001). Similarly, we observed a sixfold significant elevation of Bax/Bcl-2 protein ratio in our neonatal model of stroke in the P7 rat in the core at 48 hours postreperfusion but not in the penumbra (see Figure 42.3C). High levels of Bax immunoreactivity in many neurons undergoing apoptosis were found in one study on global ischemia (Krajewski et al., 1995).

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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