Anatomy And Function

Although a large body of literature has focused on the medial temporal lobe and the well-described age-related deficits in explicit or declarative memory that are dependent on this system, it is notable that other brain systems are also affected at advanced ages and contribute to losses in cognitive function. Frontal cortical and/or striatal circuitry is strongly affected in both normal aging and in pathological conditions associated with the aging process (i.e., Alzheimer's and Parkinson's disease). Subjects with prefrontal dysfunction are deficient in their ability to alter a behavioral response in the face of changing contingencies. This type of cognitive deficit may be caused by a disruption of striatal outflow resulting in frontal cortex dysfunction in circuitry connecting the prefrontal cortex, striatum and thalamus.

Figure 32.6 highlights the frontal cortex and striatum in the human and rat brain.

The frontal cortex (including infralimbic, prelimbic and anterior cingulater cortices) sends its major output to

Prefrontal cortex


Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment