The Major Classes Of Genetic Stocks

Table 9.1 classifies the different genetic types of laboratory mice and rats into a genetically undefined group, which includes outbred stocks, genetically heterogeneous stocks, and segregating hybrids and

Table 9.1 The Major Classes of "Genetic" Stocks

Genetically Undefined

Outbred stocks

Genetically heterogeneous stocks Outbred selected stocks Segregating hybrids Advanced intercross lines Partially Genetically Defined Mutants on an outbred background Transgenes on an outbred background Inbred strains in development Isogenic Strains Inbred strains Congenic strains Recombinant inbred strains Recombinant congenic strains Consomic strains F1 hybrids

Segregating inbred strains Clones

Monozygous twins outbred selected stocks. The genotype of any individual of this class of stock will be unknown unless the animal is individually genotyped at loci of interest. The partially isogenic group consists of stocks carrying mutants and transgenes that have a genetically heterogeneous background but in which the genotype at some loci is known, and of inbred strains in development. Finally, the isogenic family includes inbred strains, F1 hybrids, congenic strains, and others given in Table 9.1. The properties of these three main classes of stock are discussed below.

Most of the larger species of laboratory animals, such as primates, dogs, and cats, are only readily available as outbred stocks. However, there are a few colonies that carry mutations on an outbred background or have the genotype defined at some loci, such as the major histocompatibility complex. There are also some mutant stocks and inbred strains of rabbits, guinea pigs, hamsters, gerbils, and a few other species. However, with all these species, the characteristics, research uses, and maintenance are essentially the same as for mice.

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