Most laboratory animals used today are purpose bred using disease control measures equal to or superior to that in the research facility; therefore, most research facilities do not require special quarantine for the vast majority of the animals received into the facility. However, there typically are exceptions. One common exception is the result of the increased use of transgenic and knockout (TG/KO) animals and the sharing of these unique rodents (usually mice) between research institutions. Most facilities today require a high-level rodent quarantine facility for holding animals until they can be documented to be "clean" or the genetic line can be rederived by C-section or embryo transfer. Ideally, rodents of unknown health status, or worse, animals known to be infected with agents hazardous to other rodents in the facility, are best maintained in an ABSL-3 facility. At a minimum, the rodent quarantine facility should be well isolated from other rodent housing areas. Animal cubicles are a good option for quarantine areas, even when used in conjunction with microisolation cages.

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