Competition Between Microorganisms within the Animal

In some studies, experimental infection is the main detail of the study, or inactivated bacteria are used for the induction of some immunological response, so obviously, the animal should not already carry that infection. If an animal is used for propagation of viruses, it may experimentally be immuno-suppressed to make it susceptible to the inoculated virus. However, some of the organisms already present in the animal may propagate instead. Some infections, such as Corynebacterium kutscheri, Kilham rat virus, Sendai virus and sialodacryoadenitis virus213 reduces the severity of disease caused by other agents, thereby destroying infectious disease models.

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