Gastrointestinal Assessment

The gastrointestinal tract (GI) can have many abnormalities associated with it. There are various lesions occurring in the GI tract of genetically engineered mice. Some of these lesions are unique to the particular mouse line and some of them resemble human diseases. Thus, it is important to properly interpret these changes. Many of the GI diseases studied in transgenic mice involve the small intestinal tract and large intestinal tract or colon. In all cases, a thorough examination of the GI...

Present Role Of Laboratory Animals

As discussed previously, rodents, i.e., mice and rats, account for the overwhelming majority of all laboratory animals. This is reflected in the present scientific development of the exponentially growing number of genetically engineered mouse strains produced. Therefore, after outlining the contributions of a wide range of laboratory animals to Physiology and Medicine Nobel Prizes, we discuss the present role of laboratory animals in medical science, with the focus on mice. However, a final...

Human Benefits Of Animal Experimentation

Broadly speaking, modern animal experimentation began in seventeenth-century England and France. It has been central to our understanding of animal and human physiology ever since. A famous early example is William Harvey's investigation of the role of the heart in blood circulation. Observing the hearts of live animals with opened thoraxes, Harvey was able to see that the blood circulates in the body as a result of contractions of the heart. In the first place, then, when the chest of a living...

References

Bryant, D., Boscato, L.M., Mboloi, P.N., and Stuart, M.C., Allergy to laboratory animals among animal handlers, Med. J. Aust., 163, 415, 1995. 2. Teasdale, E.L., Davies, E.G., and Slovak, R., Anaphylaxis after bites by rodents, Br. Med. J, 286, 1480, 1993. 3. Hunskaar, S. and Fosse, R.T., Allergy to laboratory mice and rats A review of the pathophysiology, epidemiology, and clinical aspects, Lab. Anim., 34, 358, 1990. 4. Hunskaar, S. and Fosse, R.T., Allergy to laboratory mice and rats A...

Institute of Animal Technology IAT

IAT was created in the U.K. to attain proper recognition of the essential contributions to science of those employed to care for laboratory animals. To advance and promote excellence in the technology and practice of laboratory animal care and welfare. In education, IAT makes provision for animal technicians, technologists, and others professionally engaged in the field of animal science to receive appropriate training and qualifications, thus ensuring that they may contribute to advancing...

Ventilation

Animal facilities must have dedicated supply and exhaust air handling units. The supply air must be 100 outside makeup air. The ventilation rate that has proven effective for most animal rooms expressed in terms of fresh air changes per hour cph is around 15 cph. However, this varies between 10 and 20 cph depending on the heat load as well as microbial, particulate, and gaseous contaminants generated in the room, which is dependent on the species and density of animals to be housed in the room....