Outbred Selected Stocks

Genetic selection with the maintenance of genetic heterogeneity has been used by several investigators as a means of producing new animal models. Examples include the Biozzi mice selected for high and low immunological response to sheep red blood cells,28 SENCAR mice selected for susceptibility to skin carcinogenesis,29 the Dahl rats selectively bred for high or low blood pressure on a high salt diet,30 and several stocks of mice selected for various aspects of response to alcohol.31 This...

Lean Body Mass

Muscle wasting is a consequence of many systemic diseases such as diabetes, cancer, sepsis, hyperthy-roidism, uremia, muscle disuse, and nerve injury. Thus, muscle mass determination is important to many systemic disease studies. Muscle-specific phenotyping procedures are important and consist of an intensive anatomic evaluation that involves muscle mass determination via gross pathology and histology, followed by biochemical techniques such as molecular flux spectroscopy. Such techniques are...

Present Role Of Laboratory Animals

As discussed previously, rodents, i.e., mice and rats, account for the overwhelming majority of all laboratory animals. This is reflected in the present scientific development of the exponentially growing number of genetically engineered mouse strains produced. Therefore, after outlining the contributions of a wide range of laboratory animals to Physiology and Medicine Nobel Prizes, we discuss the present role of laboratory animals in medical science, with the focus on mice. However, a final...

Human Benefits Of Animal Experimentation

Broadly speaking, modern animal experimentation began in seventeenth-century England and France. It has been central to our understanding of animal and human physiology ever since. A famous early example is William Harvey's investigation of the role of the heart in blood circulation. Observing the hearts of live animals with opened thoraxes, Harvey was able to see that the blood circulates in the body as a result of contractions of the heart. In the first place, then, when the chest of a living...

References

Bryant, D., Boscato, L.M., Mboloi, P.N., and Stuart, M.C., Allergy to laboratory animals among animal handlers, Med. J. Aust., 163, 415, 1995. 2. Teasdale, E.L., Davies, E.G., and Slovak, R., Anaphylaxis after bites by rodents, Br. Med. J, 286, 1480, 1993. 3. Hunskaar, S. and Fosse, R.T., Allergy to laboratory mice and rats A review of the pathophysiology, epidemiology, and clinical aspects, Lab. Anim., 34, 358, 1990. 4. Hunskaar, S. and Fosse, R.T., Allergy to laboratory mice and rats A...