Gastrointestinal Assessment

The gastrointestinal tract (GI) can have many abnormalities associated with it. There are various lesions occurring in the GI tract of genetically engineered mice. Some of these lesions are unique to the particular mouse line and some of them resemble human diseases. Thus, it is important to properly interpret these changes. Many of the GI diseases studied in transgenic mice involve the small intestinal tract and large intestinal tract or colon. In all cases, a thorough examination of the GI...

Present Role Of Laboratory Animals

As discussed previously, rodents, i.e., mice and rats, account for the overwhelming majority of all laboratory animals. This is reflected in the present scientific development of the exponentially growing number of genetically engineered mouse strains produced. Therefore, after outlining the contributions of a wide range of laboratory animals to Physiology and Medicine Nobel Prizes, we discuss the present role of laboratory animals in medical science, with the focus on mice. However, a final...

Human Benefits Of Animal Experimentation

Broadly speaking, modern animal experimentation began in seventeenth-century England and France. It has been central to our understanding of animal and human physiology ever since. A famous early example is William Harvey's investigation of the role of the heart in blood circulation. Observing the hearts of live animals with opened thoraxes, Harvey was able to see that the blood circulates in the body as a result of contractions of the heart. In the first place, then, when the chest of a living...

References

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