Oral Osmotic Drugs

Orally administered osmotic drugs tend to be somewhat slower in their action but are safer compared with intravenous drugs (figure 8.3).

8.8.1 Glycerol. Glycerol has an onset of action from 10 to 30 minutes after ingestion, reaches a maximal effect in 45 to 120 minutes, and has a duration of action of 4 to 5

Figure 8.3. Representation of composite effects of mannitol (white line) and glycerol (black line) on IOP in glaucomatous patients with similar initial IOP. Oral glycerol is somewhat slower and less profound in its effect on IOP compared with intravenous mannitol. Data from Galin MA, Davidson R, Shachter N. Ophthalmological use of osmotic therapy. Am J Ophthalmol. 1966;62:629-634.

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