Neuroprotection is a therapeutic paradigm for slowing or preventing death of neurons, including retinal ganglion cells and their axons (optic nerve fibers), to maintain their physiological function.3 The underlying theoretical basis for a neuroprotective strategy in glaucoma appears sound. Moreover, considerable data from retinal ganglion cell culture and animal models of optic nerve injury support a neuropro-tective strategy. Randomized controlled trials are evaluating neuroprotective strategies in patients with glaucoma. For neuroprotection to become an integral part of our therapy for glaucoma, it is necessary that clinical research complement and extend available basic research. If neuroprotection does become a viable therapy for glaucoma, it is likely that it will be complementary, and not replace, IOP-lowering medical therapy.

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