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4 aOne patient's administration of pilocarpine as measured by medication monitor.

^ Source: Reprinted from Kass MA, Meitzer DW, Gordon M, et al. Compliance with topical pilocarpine treatment. Am J Ophthalmol.

1986;101:515-523. Copyright 1986, with permission from Elsevier Science.

persistence rates as low as 20% at 18 months17 and as high as 64% at 12 months.18 It is important to emphasize that employing large databases to study persistence is useful but has some limitations. The data consist of prescription-refill counts gathered retrospectively. Such data cannot fully account for medication prescribed to one eye only, for medication purchased outside the health system (e.g., in Mexico or Canada), or for medication prescribed for temporary conditions. Nonetheless, these data reinforce the conclusion that defaulting is a common and serious problem in glaucoma therapy.

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