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®The lower dose indicated is the preferred initial dose, and the higher dose is the maximum daily dose for treatment of systemic hypertension.

bGeneric is available.

®The lower dose indicated is the preferred initial dose, and the higher dose is the maximum daily dose for treatment of systemic hypertension.

bGeneric is available.

cA 0.1 mg dose may be given every other day.

Source: Modified from Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. JAMA. 2003;289:2560-2572.

absorption and penetration of the blood-brain barrier caused significant systemic hypotension.25

The reduction of IOP after systemic administration of clonidine is primarily due to reduced aqueous formation, probably mediated by both central and peripheral adrenergic mechanisms.25,26 This drug also causes a reduction of episcleral venous

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