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Source: David R, Spaeth GL, Clevenger, CE, et al. Brimonidine in the prevention of intraocular pressure elevation following argon laser trabeculoplasty. Arch Ophthalmol. 1993;111:1387-1390. See also Barnebey HS, Robin AL, Zimmerman TJ, et al. The efficacy of brimonidine in decreasing elevations in intraocular pressure after laser trabeculoplasty. Ophthalmology. 1993;100:1083-1088.

Source: David R, Spaeth GL, Clevenger, CE, et al. Brimonidine in the prevention of intraocular pressure elevation following argon laser trabeculoplasty. Arch Ophthalmol. 1993;111:1387-1390. See also Barnebey HS, Robin AL, Zimmerman TJ, et al. The efficacy of brimonidine in decreasing elevations in intraocular pressure after laser trabeculoplasty. Ophthalmology. 1993;100:1083-1088.

would be ideal, but since the exact mechanism of loss is not currently known, this has not been accomplished. Nevertheless, some agents have been suggested to have an effect on glaucoma that is independent of IOP. In animal models, brimonidine has been suggested to have a neuroprotective effect.100,101 In the rat optic nerve crush system, intraperitoneal injection of 100 mg/kg preserved some optic nerve function.102 In some human studies, brimonidine-treated patients were reported to have an improvement in their visual field testing.103 In another human study, brimonidine and timolol were used to control IOP, and although the IOP control was the same, there was significant preservation of the retinal nerve fiber layer by scanning laser polarimetry in the brimonidine group.104 While human studies have not conclusively shown neuroprotection, this is at least an encouraging area for further research.

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