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Combined Alpha and Beta Blockers

Carvedilol 12.5-50 Coreg

Labetalolb 200-800 Normodyne, Trandate aThe lower dose indicated is the preferred initial dose, and the higher dose is the maximum daily dose for treatment of systemic hypertension. bGeneric is available.

Source: Modified from Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. JAMA. 2003;289:2560-2572.

Figure 9.1. Significant reaction of mean IOP in six ocular hypertensive patients after oral administration of placebo (blue circles) or 80 mg propranolol (orange circles). Data from Wettrell K, Pandolfi M. Early dose response analysis of ocular hypotensive effects of pro-pranolol in patients with ocular hypertension. Br J Ophthalmol. 1976;60:680-683.

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