Fixed Combination Drugs 139

Albert S. Khouri, Tony Realini, and Robert D. Fechtner

7.1 Products of Historical Interest, 140

7.1.1 Pilocarpine-Epinephrine, 140

7.1.2 Timolol-Pilocarpine and Timolol-Epinephrine, 140

7.1.3 Betaxolol-Pilocarpine, 141

7.2 Modern Fixed Combination Approved in the United States: Timolol-Dorzolamide, 141

7.3 Modern Fixed Combinations Approved Outside the United States, 142

7.3.1 Timolol-Latanoprost, 143

7.3.2 Timolol-Travoprost, 144

7.3.3 Timolol-Bimatoprost, 145

7.3.4 Timolol-Brimonidine, 146

7.4 Conclusion, 146

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