Osmotic drugs are contraindicated in patients with well-established anuria, severe dehydration, frank or impending acute pulmonary edema, severe cardiac decompensation, or hypersensitivity to any component of the preparations.

These drugs should be administered with caution to patients with cardiac, renal, or hepatic diseases. In patients with severe impairment of renal function, a test dose (0.2g/kg of body weight, to produce urine flow of at least 30 to 50mL/h) should be performed by the internist prior to use of intravenous mannitol. Caution should be exercised, in particular, in patients with congestive heart disease, hypervolemia, electrolyte abnormalities, confused mental states, and dehydration. Oral glycerol should be used with caution in diabetic patients because the blood glucose may rise after metabolism of the drug. When osmotic drugs are administered prior to surgery, the patient's bladder should be empty.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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