Contraindications

Several contraindications to use are listed in the FDA-approved labeling for these drugs. They can be grouped in a few categories. Specific differences are noted below in the sections on adverse effects and in the sections on each compound. There is a relative or absolute contraindication in patients with pulmonary disease such as bronchial asthma and severe chronic obstructive pulmonary disease (COPD; this contraindication is not listed for betaxolol). Beta blockers affect the heart and may be contraindicated in patients with conditions such as sinus bradycardia, overt un-compensated cardiac failure, cardiogenic shock, or second- or third-degree atrio-ventricular block who do not have a pacemaker. As with all drugs, each OBB is contraindicated in patients with a hypersensitivity to any component of the product.

In addition to being aware of the contraindications listed on the product labeling, the physician must regularly reassess the health status of the patient. While it is clear that OBBs are contraindicated in patients with reactive airway disease, heart block (greater than first degree), overt congestive heart failure, and symptomatic sinus bradycardia, any patient who develops one of these conditions while using an OBB should have the OBB discontinued to see if the condition improves.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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