Cholinergic Drugs 103

B'Ann True Gabelt and Paul L. Kaufman

5.1 Mechanism of Action, 103

5.2 Contraindications, 106

5.3 Indications and Treatment, 109

5.4 Side Effects, 109

5.5 Drug Interactions, 113

5.6 Results of Clinical Trials, 114

5.7 Direct, Short-Acting Drugs, 114 5.7.1 Pilocarpine, 115

5.7.1.1 Formulations, 115

5.7.1.2 Pharmacokinetics, Concentration-Effect Relationship, and Metabolism, 115 5.7.2 Carbachol, 116

5.7.2.1 Formulations, 116

5.7.2.2 Pharmacokinetics, Concentration-Effect Relationship, and Metabolism, 117

5.8 Indirect, Long-Acting Drugs, 117 5.8.1 Echothiophate, 117

5.8.1.1 Formulations, 118

5.8.1.2 Pharmacokinetics, Concentration-Effect Relationship, and Metabolism, 118

Acknowledgment, 118

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