Types Of Intestinal Simulator Models

In vitro models can be divided into batch cultures, chemostat-type simulators, including semi-continuous and continuous cultures, and non-chemostat-type simulators. All models of the gastrointestinal tract (GIT) have strictly anaerobic conditions in order to simulate the environment that supports the growth of microbiota obtained from the GIT of humans or other mammals. In vitro models can be used sequentially, so that in the simulators of stomach and small intestine the food matrix can be digested using conditions and enzymes representing the physiological conditions in the upper GIT, while the colon simulators continue by simulating the microbial metabolism of the nondigestible residue. The different chemostat- and non-chemostat-type models have major structural differences, but the batch fermentors are generally similarly structured, small-scale bottle fermentors. The chemostat models can be run using inocula in either an in vitro steady-state (the exponential growth of the bacterial has stabilized) achieved with several days of pre-fermentation of the fecal inoculum or after a short (16-24 hours) pre-fermentation.

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