Tetracyclines

Tetracycline

The ecological effect of tetracycline hydrochloride on the gastrointestinal microbiota has been examined in healthy volunteers (83). Tetracycline had no major effect on the total numbers of intestinal microorganisms although a few subjects acquired new strains of C. albicans. However, the major finding was the emergence of resistant E. coli strains in 10 of 15 subjects.

Doxycycline

The effect of doxycycline has been evaluated in two studies in healthy subjects (83,84). The results are partly consistent in that new resistant strains were detected during treatment. Acquisition of C. albicans occurred in subjects in the first mentioned study and new strains of Enterobacteriaceae in the latter. In this study, the aerobic microbiota was also suppressed while the anaerobic microbiota was not influenced. However, the number of fusobacteria was reduced and a marked emergence of resistance was also observed in anaerobic microorganisms (84).

Pregnancy And Childbirth

Pregnancy And Childbirth

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